Thursday, August 18, 2016

Dopamine Stimulating Headphones and How They Can Change Our Definition of Being High

By Laura Morales

This post was written as part of a class assignment from students who took a neuroethics course with Dr. Rommelfanger in Paris in Summer 2016.

Laura Morales is 21 years old and originally from Panama. She is currently a senior pursuing a double major in Neuroscience and Behavioral Biology and Psychology in Emory University in Atlanta, GA.

If you have ever heard a song that sends chills down your spine, relaxes your entire body and gives you a general feeling of being close to ecstasy, you have experienced the “high-like sensation” the makers of Nervana wish to tap into. The company Nervana has designed a set of headphones that, while playing music, transcutaneously send electrical signals into the left ear to stimulate the vagus nerve to match the frequency of the beat of the music. The vagus nerve is involved with activation of the parasympathetic nervous system, which is normally activated when the body is at rest. This nerve stimulation results in the release of neurotransmitters like dopamine, serotonin and endorphins—these are transmitters thought to be related to that “feel-good” sensation (Ashby & Isen, 1999). Vagus nerve stimulation has been used to treat epilepsy (Schachter & Saper, 1998), although the mechanism through which it works is not well understood. While reducing seizures, there have also been reports that vagus nerve stimulation has improved the overall mood in people with epilepsy (Terry Jr, 2014). Transcutaneous vagus nerve stimulation has also been shown to have equivalent anticonvulsive effects as the more invasive method (Ellrich, 2011). Similar to this therapeutic approach, Nervana advertises their headphones as promoting wellness and recommends the headphones be used twice a day for 45 minutes to improve mood and increase general health.

According to the World Health Organization (WHO), a psychoactive drug is a substance that “when taken in or administered into one’s system, [affects] mental processes.” Many drugs of abuse like methamphetamine and cocaine work by modifying levels of neurotransmitters, especially dopamine (Di Chiara & Imperato, 1988). If Nervana use alters neurotransmitter levels, what makes the headphones different from consuming a drug that results in the equivalent kind and degree of neurotransmitter change?

What makes it socially acceptable (or socially insignificant) that these headphones stimulate the release of neurotransmitters, yet lack any additional regulations over the average pair of headphones? On their website, the company Nervana claims that they have found no evidence of dependence to the use of their headphones in the hundreds of humans in which they have tested the product. They also say that, because the stimulation can make the person feel more relaxed, it should not be used while operating heavy machinery—not dissimilar from warnings that come along with something like cough syrup. Even though the company has not found any signs of dependency, measuring the changes in neurotransmitter sensitivity caused by constant stimulation would require a more extensive, longitudinal study. After decades of research into the use of cannabis, only recently has it been shown that consistent use blunts the brain’s response to dopamine (Volkow et al, 2014). If constant exposure to neurotransmitter stimulation can blunt the brain’s response and increase the threshold for the neurotransmitter to have an effect, one wonders if a similar effect or desensitization would accompany long-term use of Nervana. More extensive research on the use of these headphones and how the headphones can alter brain function must be done, and if they have been done by the company, the data should be released for consumers to know that the product is safe.

Image Courtesy of Flikr user Naveen Jamal.
Neuroscientists still do not fully understand the brain’s plasticity—its way of making chemical and structural changes throughout life (Dagranski et al, 2004). Neurotransmitters seemingly are sensitive to whatever we expose ourselves to, but for some reason a pair of headphones that alter their activity seem more harmless than a chemical substance that is actively ingested but also alters neurotransmitter function.

The more we understand about neuroplasticity, the more ways we will find to push the limits, to change normal functioning and to alter the way we feel through external stimulation. Does this mean we would eventually have to revisit our meaning of what it is to be under the influence? Even though there are no imaging studies provided, there are likely to be some similarities between the dopaminergic pathways being activated by the vagus nerve stimulation of the headphones and other drugs that alter dopamine activity. Even though vagus nerve stimulation is used to treat epilepsy, there is a difference in what might be safe in a therapeutic approach versus a recreational approach and how we might weigh risks versus harms when one is sick versus healthy. While it may sound absurd to create a dependency to listening to music using a specific set of headphones, it is imperative to note that we do not understand the pathway through which they may be altering the brain.

It is difficult to see a pair of headphones as potentially presenting a risk, but if it is altering the brain’s chemical composition, even by stimulating endogenous change in the brain, it could potentially have the same effects as drug use. Of course, everything will stimulate an endogenous change in the brain (Draganski et al, 2004), whether it is via a drug or everyday learning, from the coffee you may have had this morning to reading this now. The more we learn about the brain, the more ways we will find to technologically alter it. The main issue is not that there might be a change in the brain that produces an alteration in mood, because we also rely on activities such as yoga and drinking tea to change our mood, but rather that these headphones have the potential to produce changes in ways that are unclear and therefore in ways that challenge one’s ability to mediate an endogenous change. Hence, such technologies require more cautious use and research on long-term effects and potential dependency. We must be wary about the potential risk of using neurotechnologies that might seem harmless, such as headphones, as well as the allure to experiment with novel technologies, especially when the impact of those technologies on our brains is not well understood.

References

Schachter, S. C., & Saper, C. B. (1998). Vagus nerve stimulation. Epilepsia,39(7), 677-686.

Terry Jr, R. S. (2014). Vagus nerve stimulation therapy for epilepsy. Epilepsy Topics. InTech, 139-160.

Volkow, N. D., Wang, G. J., Telang, F., Fowler, J. S., Alexoff, D., Logan, J., ... & Tomasi, D. (2014). Decreased dopamine brain reactivity in marijuana abusers is associated with negative emotionality and addiction severity. Proceedings of the National Academy of Sciences, 111(30), E3149-E3156.

Patel D., (2016), Nervana Dopamine-Stimulating Headphones Crowdfunds Nearly $600,000. The Huffington Post. Retrieved from http://www.huffingtonpost.com/deep-patel/nervana-dopamine-stimulat_b_9810332.html

Psychoactive substances (n.d.) In World Health Organization: Terminology & classification. Retrieved from http://www.who.int/substance_abuse/terminology/psychoactive_substances/en/

Di Chiara, G., & Imperato, A. (1988). Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proceedings of the National Academy of Sciences,85(14), 5274-5278.

Ashby, F. G., & Isen, A. M. (1999). A neuropsychological theory of positive affect and its influence on cognition. Psychological review, 106(3), 529.

Draganski, B., Gaser, C., Busch, V., Schuierer, G., Bogdahn, U., & May, A. (2004). Neuroplasticity: changes in grey matter induced by training. Nature,427(6972), 311-312.

Ellrich, J. (2011). Transcutaneous vagus nerve stimulation. Eur Neurol Rev,6(4), 254-6.

Want to cite this post?

Morales, Laura. (2016). Dopamine Stimulating Headphones and How They Can Change Our Definition of Being High. The Neuroethics Blog. Retrieved on , from http://www.theneuroethicsblog.com/2016/08/dopamine-stimulating-headphones-and-how.html

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